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1

Multiproxy reconstruction of oceanographic conditions in the southern epeiric Kupferschiefer Sea (Late Permian) based on redox-sensitive trace elements, molybdenum isotopes and biomarkers

Ruebsam, Wolfgang, Dickson, Alexander J., Hoyer, Eva-Maria, Schwark, Lorenz

Journal:

Gondwana Research

Year:

2017

Language:

english

File:

PDF, 3.19 MB

english, 2017

2

Cryosphere carbon dynamics control Early Toarcian global warming and sea level evolution

Ruebsam, Wolfgang, Mayer, Bernhard, Schwark, Lorenz

Journal:

Global and Planetary Change

Year:

2018

Language:

english

File:

PDF, 10.14 MB

english, 2018

3

Calibrating the Early Toarcian (Early Jurassic) with stratigraphic black holes (SBH)

Ruebsam, Wolfgang, Al-Husseini, Moujahed

Journal:

Gondwana Research

Year:

2020

File:

PDF, 4.40 MB

2020

4

Chronology of the Early Toarcian environmental crisis in the Lorraine Sub-Basin (NE Paris Basin)

Ruebsam, Wolfgang, Münzberger, Petra, Schwark, Lorenz

Journal:

Earth and Planetary Science Letters

Year:

2014

Language:

english

File:

PDF, 3.08 MB

english, 2014

5

Aromatic hydrocarbons provide new insight into carbonate concretion formation and the impact of eogenesis on organic matter

Plet, C., Grice, K., Scarlett, A.G., Ruebsam, W., Holman, A.I., Schwark, L.

Journal:

Organic Geochemistry

Year:

2019

File:

PDF, 3.16 MB

2019

6

δ13C of terrestrial vegetation records Toarcian CO2 and climate gradients

Ruebsam, Wolfgang, Reolid, Matías, Schwark, Lorenz

Journal:

Scientific Reports

Year:

2020

Language:

english

File:

PDF, 2.25 MB

english, 2020

7

A Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry

Cuozzo, John W., Clark, Matthew A., Keefe, Anthony D., Kohlmann, Anna, Mulvihill, Mark J, Ni, Haihong, Renzetti, Louis, Resnicow, Daniel I, Ruebsam, Frank, Sigel, Eric A, Thomson, Heather A, Wang, Ce,

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 1.26 MB

2020

8

Toarcian climate and carbon cycle perturbations â its impact on sea-level changes, enhanced mobilization and oxidation of fossil organic matter

Ruebsam, Wolfgang, PieÅkowski, Grzegorz, Schwark, Lorenz

Journal:

Earth and Planetary Science Letters

Year:

2020

File:

PDF, 2.68 MB

2020

9

Molecular paleothermometry of the early Toarcian climate perturbation

Ruebsam, Wolfgang, Reolid, Matias, Sabatino, Nadia, Masetti, Daniele, Schwark, Lorenz

Journal:

Global and Planetary Change

Year:

2020

File:

PDF, 15.13 MB

2020

10

ChemInform Abstract: Z-Selective Olefination of Base-Sensitive Chiral β-Hydroxy-α -aminoaldehydes Using a Modified Horner-Wadsworth-Emmons Reaction.

F. RUEBSAM, A. M. EVERS, C. MICHEL, A. GIANNIS

Journal:

Year:

1997

Language:

english

File:

PDF, 35 KB

english, 1997

11

ChemInform Abstract: Barbier-Type Allylation of Chiral α-Aminoaldehydes: Dependence of the Stereochemical Outcome on Metal and Allylic Halide.

F. RUEBSAM, S. SECK, A. GIANNIS

Journal:

Year:

1997

File:

PDF, 35 KB

1997

12

ChemInform Abstract: New Technology for the Synthesis of Vancomycin-Type Biaryl Ring Systems.

K. C. NICOLAOU, X.-J. CHU, J. M. RAMANJULU, S. NATARAJAN, S. BRAESE, F. RUEBSAM, C. N. C. BODDY

Journal:

Year:

1997

File:

PDF, 31 KB

1997

13

ChemInform Abstract: Peptidomimetics in Drug Design

A. GIANNIS, F. RUEBSAM

Journal:

Year:

1997

File:

PDF, 24 KB

1997

14

ChemInform Abstract: A Suzuki Coupling—Macrolactamization Approach to the AB-COD Bicyclic System of Vancomycin.

K. C. NICOLAOU, J. M. RAMANJULU, S. NATARAJAN, S. BRAESE, H. LI, C. N. C. BODDY, F. RUEBSAM

Journal:

Year:

1998

File:

PDF, 35 KB

1998

15

ChemInform Abstract: Expeditious Routes to Evernitrose and Vancosamine Derivatives and Synthesis of a Model Vancomycin Aryl Glycoside.

K. C. NICOLAOU, H. J. MITCHELL, F. L. VAN DELFT, F. RUEBSAM, R. M. RODRIGUEZ

Journal:

Year:

1998

File:

PDF, 42 KB

1998

16

ChemInform Abstract: Synthesis of Chiral Piperazinones as Versatile Scaffolds for Peptidomimetics.

Frank Ruebsam, Ralph Mazitschek, Athanassios Giannis

Journal:

Year:

2001

File:

PDF, 29 KB

2001

17

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

Sun Hee Kim, Martin T. Tran, Frank Ruebsam, Alan X. Xiang, Benjamin Ayida, Helen McGuire, David Ellis, Julie Blazel, Chinh V. Tran, Douglas E. Murphy, Stephen E. Webber, Yuefen Zhou, Amit M. Shah, Mei

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 416 KB

english, 2008

18

5,5′- and 6,6′-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

David A. Ellis, Julie K. Blazel, Chinh V. Tran, Frank Ruebsam, Douglas E. Murphy, Lian-Sheng Li, Jingjing Zhao, Yuefen Zhou, Helen M. McGuire, Alan X. Xiang, Stephen E. Webber, Qiang Zhao, Qing Han, C

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 452 KB

english, 2009

19

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents

Yuefen Zhou, Lian-Sheng Li, Peter S. Dragovich, Douglas E. Murphy, Chinh V. Tran, Frank Ruebsam, Stephen E. Webber, Amit M. Shah, Mei Tsan, April Averill, Richard E. Showalter, Rupal Patel, Qing Han,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 293 KB

english, 2008

20

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine

Yuefen Zhou, Stephen E. Webber, Douglas E. Murphy, Lian-Sheng Li, Peter S. Dragovich, Chinh V. Tran, Zhongxiang Sun, Frank Ruebsam, Amit M. Shah, Mei Tsan, Richard E. Showalter, Rupal Patel, Bin Li, Q

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 321 KB

english, 2008

21

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

Lian-Sheng Li, Yuefen Zhou, Douglas E. Murphy, Nebojsa Stankovic, Jingjing Zhao, Peter S. Dragovich, Thomas Bertolini, Zhongxiang Sun, Benjamin Ayida, Chinh V. Tran, Frank Ruebsam, Stephen E. Webber,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 331 KB

english, 2008

22

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Frank Ruebsam, Stephen E. Webber, Martin T. Tran, Chinh V. Tran, Douglas E. Murphy, Jingjing Zhao, Peter S. Dragovich, Sun Hee Kim, Lian-Sheng Li, Yuefen Zhou, Qing Han, Charles R. Kissinger, Richard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 234 KB

english, 2008

23

4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

David A. Ellis, Julie K. Blazel, Stephen E. Webber, Chinh V. Tran, Peter S. Dragovich, Zhongxiang Sun, Frank Ruebsam, Helen M. McGuire, Alan X. Xiang, Jingjing Zhao, Lian-Sheng Li, Yuefen Zhou, Qing H

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 1.27 MB

english, 2008

24

Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Frank Ruebsam, Zhongxiang Sun, Benjamin K. Ayida, Stephen E. Webber, Yuefen Zhou, Qiang Zhao, Charles R. Kissinger, Richard E. Showalter, Amit M. Shah, Mei Tsan, Rupal Patel, Laurie A. LeBrun, Ruhi Ka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 308 KB

english, 2008

25

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents

Peter S. Dragovich, Julie K. Blazel, David A. Ellis, Qing Han, Ruhi Kamran, Charles R. Kissinger, Laurie A. LeBrun, Lian-Sheng Li, Douglas E. Murphy, Michael Noble, Rupal A. Patel, Frank Ruebsam, Mari

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 214 KB

english, 2008

26

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Frank Ruebsam, Chinh V. Tran, Lian-Sheng Li, Sun Hee Kim, Alan X. Xiang, Yuefen Zhou, Julie K. Blazel, Zhongxiang Sun, Peter S. Dragovich, Jingjing Zhao, Helen M. McGuire, Douglas E. Murphy, Martin T.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 266 KB

english, 2009

27

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Frank Ruebsam, Douglas E. Murphy, Chinh V. Tran, Lian-Sheng Li, Jingjing Zhao, Peter S. Dragovich, Helen M. McGuire, Alan X. Xiang, Zhongxiang Sun, Benjamin K. Ayida, Julie K. Blazel, Sun Hee Kim, Yue

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.97 MB

english, 2009

28

Regiospecific synthesis of 1,5-disubstituted-1H-pyrazoles containing differentiated 3,4-dicarboxylic acid esters via Suzuki coupling of the corresponding 5-trifluoromethane sulfonates

Peter S. Dragovich, Thomas M. Bertolini, Benjamin K. Ayida, Lian-Sheng Li, Douglas E. Murphy, Frank Ruebsam, Zhongxiang Sun, Yuefen Zhou

Journal:

Year:

2007

Language:

english

File:

PDF, 659 KB

english, 2007

29

Efficient synthesis of (1R,2S) and (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form

Peter S. Dragovich, Douglas E. Murphy, Kimkim Dao, Sun Hee Kim, Lian-Sheng Li, Frank Ruebsam, Zhongxiang Sun, Chinh V. Tran, Alan X. Xiang, Yuefen Zhou

Journal:

Tetrahedron: Asymmetry

Year:

2008

Language:

english

File:

PDF, 568 KB

english, 2008

30

Efficient synthesis of 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters

Douglas E. Murphy, Peter S. Dragovich, Benjamin K. Ayida, Thomas M. Bertolini, Lian-Sheng Li, Frank Ruebsam, Nebojsa S. Stankovic, Zhongxiang Sun, Jingjing Zhao, Yuefen Zhou

Journal:

Tetrahedron Letters

Year:

2008

Language:

english

File:

PDF, 156 KB

english, 2008

31

Generalized pustular psoriasis induced by systemic glucocorticosteroids: four cases and recommendations for treatment

M. Brenner, S. Molin, K. Ruebsam, P. Weisenseel, T. Ruzicka, J.C. Prinz

Journal:

British Journal of Dermatology

Year:

2009

Language:

english

File:

PDF, 327 KB

english, 2009

32

Potent HCV NS5B Polymerase Inhibitors Derived From 5-Hydroxy-3(2H)-Pyridazinones: Part 1: Exploration of Pyridazinone 4-Substituent Variation

Y. Zhou, L.-S. Li, S. Webber, P. Dragovich, D. Murphy, C. Tran, F. Ruebsam, A. Shah, M. Tsan, R. Showalter, J. Brooks, E. Okamoto, T. Nolan, D.A. Norris, L. Kirkovsky

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 58 KB

english, 2007

33

Fourier-transform EPR investigation of photo-generated radical anions of C60 in solution

Ruebsam, M., Dinse, K. P., Plueschau, M., Fink, J., Kraetschmer, W., Fostiropoulos, K., Taliani, C.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 787 KB

english, 1992

34

Efficient Large-Scale Synthesis of 2-Amino-5-methanesulfonylaminobenzenesulfonamide

Dragovich, Peter S., Murphy, Douglas E., Tran, Chinh V., Ruebsam, Frank

Journal:

Synthetic Communications

Year:

2008

Language:

english

File:

PDF, 122 KB

english, 2008

35

Reply to the comment by Boulila and Hinnov towards “Chronology of the Early Toarcian environmental crisis in the Lorraine Sub-Basin (NE Paris Basin)” by W. Ruebsam, P. Münzberger, and L. Schwark [Earth and Planetary Science Letters 404 (2014) 273–282]

Ruebsam, Wolfgang, Münzberger, Petra, Schwark, Lorenz

Journal:

Earth and Planetary Science Letters

Year:

2015

Language:

english

File:

PDF, 1.29 MB

english, 2015

36

Synthesis of New Pyridazinone Derivatives: 2,6-Disubstituted 5-Hydroxy-3(2 H )-pyridazinone-4-carboxylic Acid Ethyl Esters

Li, Lian-Sheng, Zhou, Yuefen, Zhao, Jingjing, Dragovich, Peter, Stankovic, Nebojsa, Bertolini, Thomas, Murphy, Douglas, Sun, Zhongxiang, Tran, Chinh, Ayida, Benjamin, Ruebsam, Frank, Webber, Stephen

Journal:

Year:

2007

Language:

english

File:

PDF, 196 KB

english, 2007

37

Regiospecific Synthesis of Novel 6-Amino-5-hydroxypyridazin-3(2 H )-ones

Dragovich, Peter, Blazel, Julie, Dao, Kimkim, Ellis, David, Li, Lian-Sheng, Murphy, Douglas, Ruebsam, Frank, Tran, Chinh, Zhou, Yuefen

Journal:

Year:

2008

Language:

english

File:

PDF, 136 KB

english, 2008

38

Microbially-mediated fossil-bearing carbonate concretions and their significance for palaeoenvironmental reconstructions: A multi-proxy organic and inorganic geochemical appraisal

Plet, C., Grice, K., Pagès, A., Ruebsam, W., Coolen, M.J.L., Schwark, L.

Journal:

Chemical Geology

Year:

2016

Language:

english

File:

PDF, 1.67 MB

english, 2016

39

Sabbatical Leave in Land-Grant Institutions

Journal:

Bulletin of the American Association of University Professors

Year:

1947

Language:

english

File:

PDF, 443 KB

english, 1947

40

430 Tissue polarization of mechano-adhesive signals, cytoskeleton and EGFR signaling controls skin barrier formation

Ruebsam, M., Mertz, A., Goranci, G., Horsley, V., Dufresne, E., Ziegler, W., Kubo, A., Amagai, M., Niessen, C.M.

Journal:

The Journal of Investigative Dermatology

Year:

2016

Language:

english

File:

PDF, 51 KB

english, 2016

41

Novel non-cell autonomous role of epidermal polarity protein Par3 in melanocyte homeostasis and melanomagenesis

Mescher, Melina, Ruebsam, Matthias, Jeong, Peter, Kranen, Marina, Landsberg, Jennifer, Schlaak, Max, Mauch, Cornelia, Niessen, Carien M., Tueting, Thomas, Iden, Sandra

Journal:

Journal of Dermatological Science

Year:

2016

Language:

english

File:

PDF, 52 KB

english, 2016

42

Classical cadherins control polarized organization of junctions and cytoskeleton in stratified epithelia

Ruebsam, Matthias, Kubo, Akiharu, Mertz, Aaron, Boggetti, Barbara, Goranci, Gladiola, Dufresne, Eric, Horsley, Valerie, Amagai, Masayuki, Niessen, Carien M.

Journal:

Journal of Dermatological Science

Year:

2016

Language:

english

File:

PDF, 50 KB

english, 2016

43

From ultrafast to slow: Heating rate dependence of the glass transition temperature in metallic systems

Küchemann, Stefan, Gibbins, Goodwin, Corkerton, Joe, Brug, Eleanor, Ruebsam, Jonas, Samwer, Konrad

Journal:

Philosophical Magazine Letters

Year:

2016

Language:

english

File:

PDF, 1.13 MB

english, 2016

44

Impact of climate change on the magnetic mineral assemblage in marine sediments from Izu rear arc, NW Pacific Ocean, over the last 1 Myr

Kars, Myriam, Musgrave, Robert J., Kodama, Kazuto, Jonas, Ann-Sophie, Bordiga, Manuela, Ruebsam, Wolfgang, Mleneck-Vautravers, Maryline J., Bauersachs, Thorsten

Journal:

Palaeogeography, Palaeoclimatology, Palaeoecology

Year:

2017

Language:

english

File:

PDF, 3.49 MB

english, 2017

45

Palaeobiology of red and white blood cell-like structures, collagen and cholesterol in an ichthyosaur bone

Plet, Chloé, Grice, Kliti, Pagès, Anais, Verrall, Michael, Coolen, Marco J. L., Ruebsam, Wolfgang, Rickard, William D. A., Schwark, Lorenz

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.56 MB

english, 2017

46

Environmental response to the early Toarcian carbon cycle and climate perturbations in the northeastern part of the West-Tethys shelf

Ruebsam, Wolfgang, Müller, Tamás, Kovács, János, Pálfy, József, Schwark, Lorenz

Journal:

Gondwana Research

Year:

2018

Language:

english

File:

PDF, 2.99 MB

english, 2018

47

870 E-cadherin binds desmoglein to facilitate desmosome assembly

Ruebsam, M., Shafraz, O., Stanley, S., Kowalczyk, A.P., Niessen, C., Sivasankar, S.

Journal:

The Journal of Investigative Dermatology

Year:

2018

Language:

english

File:

PDF, 240 KB

english, 2018

48

731 The polarity protein atypical kinase C controls desmosome organization and adhesive strength

Tellkamp, F., Ruebsam, M., Nolte, H., Rinschen, M., Green, K.J., Krüger, M., Niessen, C.

Journal:

The Journal of Investigative Dermatology

Year:

2018

Language:

english

File:

PDF, 203 KB

english, 2018

49

Flavonol biosynthesis genes and their use in a synthetic biology approach to engineering the plant antidiabetic metabolite montbretin A

Irmisch, Sandra, Ruebsam, Henriette, Jancsik, Sharon, Yuen, Macaire M.S., Madilao, Lina, Bohlmann, Joerg

Journal:

PLANT PHYSIOLOGY

Year:

2019

Language:

english

File:

PDF, 1.31 MB

english, 2019

50

Flavonol biosynthesis genes and their use in a synthetic biology approach to engineering the plant antidiabetic metabolite montbretin A

Irmisch, Sandra, Ruebsam, Henriette, Jancsik, Sharon, Yuen, Macaire M.S., Madilao, Lina, Bohlmann, Joerg

Journal:

PLANT PHYSIOLOGY

Year:

2019

File:

PDF, 1.31 MB

2019